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Immunotherapies for Life

GD2

Bone Marrow Minimal Residual Disease Was an Early Response Marker and a Consistent Independent Predictor of Survival After Anti-GD2 Immunotherapy

Nai-Kong V. Cheung, Irina Ostrovnaya, Deborah Kuk, and Irene Y. Cheung, American Society of Clinical Oncology, 2015, Mar 1;33(7):755-63. Doi: 10.1200/JCO.2014.57.6777

GD2

Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD2 Using an IgG-scFv Bispecific Antibody with High Affinity for GD2 and DOTA Metal Complex

Sarah M. Cheal, Hong Xu, Hong-fen Guo, et al. Mol Cancer Ther 2014;13:1803-1812. Published OnlineFirst June 18, 2014.

GD2

Structure based refinement of a humanized monoclonal antibody that targets tumor antigen disialoganglioside GD2

Mahiuddin Ahmed, Jian Hu and Nai-KongV. Cheung. Frontiers in immunology 2014, doi: 10.3389/fimmu.2014.00372

GD2

Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody

Xu H, Cheng M, Guo HF, Chen Y, Huse M, Cheung NKV. Cancer Immunology Research 2014, 3(3):266-277, 2015. doi: 10.1158/2326-6066.CIR-14-0230-T. Epub 2014 Dec 26.

GD2

GD2-Targeted Immunotherapyand Radioimmunotherapy

Konstantin Dobrenkov and Nai-KongV.Cheung, Seminars inOncology, Vol 41, No5, October 2014, pp 589-612

B7-H3

The potential of theragnostic 124I-8H9 convection-enhanced delivery in diffuse intrinsic pontine glioma

Neal Luther, Zhiping Zhou, Pat Zanzonico, Nai-Kong Cheung, John Humm, Mark A. Edgar, and Mark M. Souweidane. Neuro-Oncology 2014; 0, 1-7, doi:10.1093/neuonc/not298

B7-H3

Humanized Affinity-Matured Monoclonal Antibody 8H9 Has Potent Anti-Tumor Activity and Binds to FG Loop of B7-H3.

Ahmed M, Cheng M, Zhao Q, Yehuda G, Cheal SM, Guo HF, Larson SM, and Cheung NK. Journal of Biological Chemistry 2015, doi: 10.1074/jbc.M115.679852

B7-H3

The potential of theranostic 124I-8H9 convection-enhanced delivery in diffuse intrinsic pontine glioma.

Luther N, Zhou Z, Zanzonico P, Cheung NK, Humm J, Edgar MA, Souweidane MM. Neuro-Oncology 16(6): 800-806, 2014. doi: 10.1093/neuonc/not298. Epub 2014 Feb 12.

B7-H3

Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma.

Kramer K, Kushner BH, Modak S, Pandit-Taskar N, Smith-Jones P, Zanzonico P, Humm JL, Xu H, Wolden SL, Souweidane MM, Larson SM, Cheung NK. J Neurooncol. 2010 May;97(3):409-18. doi: 10.1007/s11060-009-0038-7, Epub 2009 Nov 5.

BiTE

Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy

Ming Cheng, Mahiuddin Ahmed, Hong Xu and Nai-Kong V. Cheung, International Journal of Cancer, pages 476–486, 15 January 2015, DOI: 10.1002/ijc.29007

Bispecific Antibodies

Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody

Mahiuddin Ahmed, Ming Cheng, Irene Y. Cheung and Nai-Kong V. Cheung, Oncoimmunology, 2015 Apr 27;4(4):e989776.