Central Nervous System (CNS)/Leptomeningeal Metastases (LM)

Y-mAbs is currently studying a treatment for LM. See the trial details here.

When cancer cells are found in either the meninges (the membrane surrounding the brain and spinal cord) or cerebrospinal fluid, they are called leptomeningeal metastases, or LM.

LM are a rare and difficult-to-treat late-stage complication, often associated with neuroblastoma, medulloblastoma, and other cancers in which cancer cells from other affected areas spread to the meninges. Symptoms of LM vary, but can include difficulty with mental functioning and/or double vision, and can lead to decreased quality of life. LM are usually diagnosed through an MRI (magnetic resonance imaging) scan or spinal tap.

If LM are found, treatment aims to relieve symptoms and eliminate the cancer cells. Common therapeutic choices often include radiation to the sites that have been affected, followed by chemotherapy.

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