Diffuse Intrinsic Pontine Glioma (DIPG)

Y-mAbs is currently studying a treatment for DIPG. See the trial details here.

DIPG is a highly aggressive and difficult to treat brain tumor found at the base of the brain in children and some adults. Diagnosis usually occurs between the ages of 5 and 7. DIPG is a devastating condition that interferes with all bodily functions—taking away the ability to move, talk, or even do the most basic things, such as eating or drinking.

DIPG causes pressure to build up inside the nerves in the brain and skull, and symptoms usually get worse quickly.

The treatment of DIPG has been very limited. Radiation has been used to shrink and/or eliminate the cancerous cells, which can help improve how a child feels, but is also challenging due to the nature of the condition. Chemotherapy has not been shown to be effective in DIPG. Recently, however, advanced immunotherapeutic options are being studied for their effect on DIPG.

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